Ligature-induced periodontitis induces systemic inflammation but does not alter acute outcome after stroke in mice.
Conor O'BoyleMichael J HaleyEloïse LemarchandCraig J SmithStuart M AllanJoanne E KonkelCatherine B LawrencePublished in: International journal of stroke : official journal of the International Stroke Society (2019)
Our data show that despite elevated systemic inflammation in periodontitis, oral inflammatory disease does not impact acute stroke pathology in terms of severity, determined primarily by infarct volume. This indicates that, at least in this experimental paradigm, periodontitis alone does not alter acute outcome after cerebral ischemia.
Keyphrases
- cerebral ischemia
- liver failure
- drug induced
- respiratory failure
- subarachnoid hemorrhage
- brain injury
- aortic dissection
- blood brain barrier
- high glucose
- hepatitis b virus
- electronic health record
- diabetic rats
- heart failure
- type diabetes
- coronary artery disease
- adipose tissue
- endothelial cells
- big data
- artificial intelligence
- mechanical ventilation