Temporal trends and transmission dynamics of pre-treatment HIV-1 drug resistance within and between risk groups in Kenya, 1986-2020.
George M NduvaFrederick OtienoJoshua KimaniYiakon SeinDawit A ArimideLyle R MckinnonFrancois CholetteMorris K LawrenceMaxwell MajiwaMoses MasikaGaudensia MutuaOmu AnzalaSusan M GrahamLarry GelmonMatt A PriceAdrian D SmithRobert C BaileyPatrik MedstrandEduard J SandersJoakim EsbjörnssonAmin S HassanPublished in: The Journal of antimicrobial chemotherapy (2023)
Compared to HETs, children and key populations had higher levels of pre-treatment HIVDR. Introduction of INSTIs after 2017 may have abrogated the increase in pre-treatment RTI mutations, albeit in the HET population only. Taken together, our findings underscore the need for targeted efforts towards equitable access to ART for children and key populations in Kenya.