Endothelial genetic deletion of CD147 induces changes in the dual function of the blood-brain barrier and is implicated in Alzheimer's disease.

Hao WangJian-Jun LvYu ZhaoHao-Lin WeiTian-Jiao ZhangHai-Jiao YangZhi-Nan Chen Jian-Li Jiang

Published in: CNS neuroscience & therapeutics (2021)

Our findings suggested that targeting CD147 in BECs may represent a novel therapeutic strategy, which promoted the design of future experimental investigations and the mechanistic understanding of neurodegenerative diseases.

Keyphrases

nk cells
endothelial cells
genome wide
cognitive decline
current status
cancer therapy
gene expression
dna methylation