A new mechanism for cannabidiol in regulating the one-carbon cycle and methionine levels in Dictyostelium and in mammalian epilepsy models.
Christopher J PerryPaul FinchAnnette Müller-TaubenbergerKit-Yi LeungEleanor C WarrenJoseph Damstra-OddyDevdutt SharmaPabitra H PatraSarah GlynJoanna BoberskaBalint StewartAmy BaldwinFabiana PiscitelliRobert J HarveyAdrian HarwoodChristopher ThompsonSandrine P ClausNicholas D E GreeneAlister James McNeishClaire M WilliamsBenjamin J WhalleyRobin Simon Brooke WilliamsPublished in: British journal of pharmacology (2020)
Our results suggest a novel mechanism for CBD in the regulating methionine levels and identify altered one-carbon metabolism in Dravet syndrome and seizure activity.
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