Empagliflozin-Pretreated Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Attenuated Heart Injury.

Boyu Chi Ailin Zou Lipeng Mao Dabei Cai Tingting Xiao Yu Wang Qingjie Wang Yuan Ji Ling Sun

Published in: Oxidative medicine and cellular longevity (2023)

Our data suggest that EMPA-sEV significantly improve cardiac repair after MI by inhibiting myocardial apoptosis. miR-214-3p at least partially mediated the myocardial protection of EMPA-sEV through the AKT signaling pathway.

Keyphrases

signaling pathway
left ventricular
pi k akt
cell cycle arrest
heart failure
epithelial mesenchymal transition
induced apoptosis
oxidative stress
bone marrow
endoplasmic reticulum stress
stem cells
cell death
electronic health record
cell proliferation
atrial fibrillation
data analysis
machine learning