Sex-Specific Negative Association between Iron Intake and Cellular Aging Markers: Mediation Models Involving TNFα.
Jie YuHaibin LiuShuli HePingping LiChunxiao MaMinglei MaYiwen LiuLu LvFan PingHuabing ZhangWei LiQi SunLingling XuYu-Xiu LiPublished in: Oxidative medicine and cellular longevity (2019)
The study found sex-specific negative associations between dietary iron intake and cellular aging markers in that iron intake had deleterious effects on LTL attrition in women and mtDNAcn in men; only the former was partly mediated by TNFα. Consequently, when dietary iron intake and iron supplementation is recommended, the effects of iron imbalance on genomic stability and cellular aging markers must be considered.