Neuroprotective Effect of Intravitreal Single-Dose Lithium Chloride after Optic Nerve Injury in Rats.

Moein AlaRazieh Mohammad JafariHossein NematianMohammad Reza GanjedaneshAsieh NaderiMostafa AkbarianiMehdi SanatkarLeila SatarianMasoud Aghsaei FardAhmad Reza Dehpour

Published in: Current eye research (2020)

It seems intravitreally lithium has optic nerve neuroprotective effects by various mechanisms like overexpression of antiapoptotic proteins, suppressing proinflammatory molecules and proapoptotic factors, and decreasing nitric oxide.

Keyphrases

optic nerve
nitric oxide
optical coherence tomography
solid state
diabetic retinopathy
vascular endothelial growth factor
cell proliferation
nitric oxide synthase
signaling pathway
transcription factor
hydrogen peroxide
cerebral ischemia
age related macular degeneration
endothelial cells