Mycobacterium tuberculosis Sub-Lineage 4.2.2/SIT149 as Dominant Drug-Resistant Clade in Northwest Ethiopia 2020-2022: In-silico Whole-Genome Sequence Analysis.
Daniel MekonnenAbaineh MunsheaEndalkachew Nibret SemegnBethlehem AdnewHailu GetachewAmiro KebedeAnanya GebrewahidSilvia Herrera-LeonAranzazu Amor AramendiaAgustín BenitoEstefanía AbascalCamille JacquelineAbraham AseffaLaura Herrera-LeonPublished in: Infection and drug resistance (2023)
The high prevalence of drug-resistant TB due to geographically restricted sub-lineages (L4.2.2.ETH) indicates the ongoing local micro epidemics. The Mtb drug resistance surveillance system must be improved. Further evolutionary analysis of L4.2.2.ETH strain is highly desirable to understand evolutionary forces that leads L4.2.2.ETH in to high level DR and transmissible sub-lineage.