A new KSRP-binding compound suppresses distant metastasis of colorectal cancer by targeting the oncogenic KITENIN complex.

Jeong A BaeWoo Kyun BaeSung Jin KimYoo-Seung KoKeon Young KimSo-Yeon ParkYoung Hyun YuEun Ae KimIk Joo ChungHangun KimHyung-Ho HaKyung Keun Kim

Published in: Molecular cancer (2021)

DKC1125 targets the KITENIN complex and could therefore be used as a novel therapeutic to suppress liver metastasis in CRC expressing high levels of KITENIN.

Keyphrases

lymph node
signaling pathway
transcription factor
dna binding