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Deletion of VPS50 protein in mouse brain impairs synaptic function and behavior.

Constanza Ahumada-MarchantCarlos Ancatén-GonzalezHenny HaensgenBastian BrauerNicolas Merino-VelizRita DrosteFelipe ArancibiaH Robert HorvitzMartha Constantine-PatonGloria ArriagadaAndrés E ChávezFernando Jose Bustos
Published in: BMC biology (2024)
We propose that VPS50 functions as an accessory protein to aid the recruitment of the V-ATPase V1 domain to synaptic vesicles and in that way plays a crucial role in controlling synaptic vesicle acidification. Understanding the mechanisms controlling behaviors and synaptic function in ASD-associated mutations is pivotal for the development of targeted interventions, which may open new avenues for therapeutic strategies aimed at ASD and related conditions.
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