Renal cancer secretome induces migration of mesenchymal stromal cells.

Piotr PopławskiWeronika Zarychta-WiśniewskaAnna BurdzińskaJoanna BogusławskaAnna Adamiok-OstrowskaKarolina HanusekBeata RybickaAlex BiałasHelena KossowskaRoksana Iwanicka-RokickaMarta KoblowskaLeszek PączekAgnieszka Piekiełko-Witkowska

Published in: Stem cell research & therapy (2023)

Advanced RCC cells secrete AREG, FN1 and HA to induce MSCs migration, while DPP4 loss prevents its inhibitory effect on MSCs homing. RCC secretome induces MSCs' transcriptional reprograming to facilitate their migration. The identified components of RCC secretome represent potential therapeutic targets.

Keyphrases

mesenchymal stem cells
renal cell carcinoma
umbilical cord
induced apoptosis
bone marrow
papillary thyroid
gene expression
cell cycle arrest
transcription factor
cell death
risk assessment
signaling pathway
human health
cell proliferation
heat shock protein