Macrophage-derived extracellular vesicles trigger non-canonical pyroptosis in chondrocytes leading to cartilage catabolism in osteoarthritis.

Taku EbataMohamad Alaa TerkawiKeita KitaharaSyunichi YokotaJunki ShiotaYoshio NishidaGen MatsumaeHend AlhasanMasanari HamasakiKazutoshi HontaniTomohiro ShimizuDaisuke TakahashiTsutomu EndoTomohiro OnoderaKen KadoyaNorimasa Iwasaki

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2023)

Our results provide a new insight into the pathological mechanisms of OA and suggest that non-canonical pyroptosis in chondrocytes represents an attractive therapeutic target for future treatment.

Keyphrases

extracellular matrix
nlrp inflammasome
knee osteoarthritis
adipose tissue
combination therapy
replacement therapy