Dental follicle mesenchymal stem cells down-regulate Th2-mediated immune response in asthmatic patients mononuclear cells.
Deniz GencN ZibandehE NainM GökalpA O ÖzenM K GökerT AkkoçPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2018)
Dental follicle mesenchymal stem cells suppressed allergen-induced Th2-cell polarisation in favour of Th1 responses and attenuated antigen-presenting cell co-stimulatory activities. These studies suggest that DFSC-based cell therapy may provide pro-tolerogenic immunomodulation relevant to allergic diseases such as asthma.
Keyphrases
- cell therapy
- mesenchymal stem cells
- umbilical cord
- immune response
- stem cells
- dendritic cells
- end stage renal disease
- allergic rhinitis
- bone marrow
- induced apoptosis
- single cell
- newly diagnosed
- chronic kidney disease
- oral health
- chronic obstructive pulmonary disease
- diabetic rats
- cell cycle arrest
- regulatory t cells
- peripheral blood
- cystic fibrosis
- patient reported outcomes
- high glucose
- cell death
- case report
- cell proliferation
- inflammatory response
- drug induced
- atopic dermatitis