Outcomes and clinical implications of intranasal insulin on cognition in humans: A systematic review and meta-analysis.
Sally WuNicolette StogiosMargaret HahnJanani NavagnanavelZahra EmamiAraba ChintohPhilip GerretsenAriel Graff-GuerreroTarek K RajjiGary RemingtonSri Mahavir AgarwalPublished in: PloS one (2023)
This review demonstrates that INI may be associated with pro-cognitive benefits for global cognition, specifically for individuals with AD/MCI. Further studies are required to better understand the neurobiological mechanisms and differences in etiology to dissect the intrinsic and extrinsic factors contributing to the treatment response of INI.