The impact of the origin of surgical sperm retrieval on placental and embryonic development: The Rotterdam Periconception cohort.

Jeffrey Hoek Willem P A BoellaardEva S van MarionSten P WillemsenEsther B BaartRégine Patricia Maria Steegers-TheunissenSam Schoenmakers

Published in: Andrology (2020)

Here we demonstrate that the first-trimester growth trajectory of the placenta is increased in pregnancies conceived after TESE-ICSI compared to those conceived after ICSI with ejaculated sperm. Findings are discussed in the light of known differences in sperm DNA integrity, epigenetics, and placental gene expression.

Keyphrases

gene expression
pregnancy outcomes
circulating tumor
single molecule
preterm birth
cell free
pregnant women
gestational age
circulating tumor cells