Time course of blood lactate levels, inflammation, and mitochondrial function in experimental sepsis.

Thiago Domingos CorreaAdriano José PereiraSebastian BrandtMadhusudanarao VudaSiamak DjafarzadehJukka TakalaStephan Mathias Jakob

Published in: Critical care (London, England) (2017)

A decrease in Lac >10% during early resuscitation (6 h) after abdominal sepsis is associated with lower levels of plasma interleukin-6 and improved brain but not hepatic or muscle mitochondrial respiration. Blood flow redistribution to abdominal organs in animals with early decrease in Lac concentrations increases the potential to both deliver and extract Lac.

Keyphrases

blood flow
oxidative stress
septic shock
acute kidney injury
intensive care unit
cardiac arrest
skeletal muscle
white matter
resting state
cardiopulmonary resuscitation
brain injury
human health
risk assessment
functional connectivity
climate change