Association between plasma imatinib levels and response to treatment of chronic myeloid leukemia in patients from Manaus, Brazil.

Maíra Araújo HenriquesFrank do Carmo Guedes JúniorLílian Minako KarubeRosângela Santos de AbreuJosé Pereira de Moura NetoIgor Rafael Dos Santos Magalhães

Published in: Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners (2024)

Approximately two-thirds of patients were classified in the drug-level range considered therapeutic, and there was a correlation between plasma concentration and higher molecular response. Additionally, most individuals had the normal genotype for the ABCG2 C421A polymorphism but further studies should be performed to reveal the role of this variable in the outcome of the disease in this population.

Keyphrases

end stage renal disease
chronic myeloid leukemia
ejection fraction
prognostic factors
peritoneal dialysis
gene expression
dna methylation
single molecule
drug induced