Epigenetic regulation of vascular smooth muscle cell phenotypic switch and neointimal formation by PRMT5.

Ni ZhuZhi-Fu GuoKyosuke KazamaBing YiNopprarat TongmuangHuijun YaoRuifeng YangChen ZhangYongwen QinLin HanJianxin Sun

Published in: Cardiovascular research (2023)

Our results identify PRMT5 as a novel regulator in VSMC phenotypic switch and suggest that inhibition of PRMT5 may represent an effective therapeutic strategy for proliferative vascular diseases.

Keyphrases

smooth muscle
single cell
cell therapy
transcription factor
stem cells