Poor association between dihydropyrimidine dehydrogenase (DPYD) genotype and fluoropyrimidine-induced toxicity in an Asian population.

Masashi KanaiTakahisa KawaguchiMasahito KotakaDai ManakaJunichi HasegawaAkinori TakaganeYoshinori MunemotoTakeshi KatoTetsuya EtoTetsuo TouyamaTakanori MatsuiKatsunori ShinozakiShigemi MatsumotoTsunekazu MizushimaMasaki MoriJunichi SakamotoAtsushi OhtsuTakayuki YoshinoShigetoyo SajiFumihiko Matsuda

Published in: Cancer medicine (2022)

These data suggested that the DPYD genotype registered in CPIC plays a minor role in FP-related toxicities in an Asian population.

Keyphrases

oxidative stress
high glucose
diabetic rats
electronic health record
big data
endothelial cells
data analysis