Inhibition of Endocytosis of Clathrin-Mediated Angiotensin II Receptor Type 1 in Podocytes Augments Glomerular Injury.

Kazunori InoueXuefei TianHeino VelazquezKeita SodaZhen WangChristopher E PedigoYing WangElizabeth CrossMarwin GroenerJee-Won ShinWei LiHossam HassanKoichi YamamotoPeter MundelShuta Ishibe

Published in: Journal of the American Society of Nephrology : JASN (2019)

Our results indicate that inhibiting aberrant podocyte-associated AT1aR signaling pathways has a protective effect in maintaining the integrity of the glomerular filtration barrier.

Keyphrases

angiotensin ii
diabetic nephropathy
high glucose
signaling pathway
endothelial cells
angiotensin converting enzyme
vascular smooth muscle cells
pi k akt
epithelial mesenchymal transition
induced apoptosis
oxidative stress