Circulating tumor DNA in patients with locally advanced rectal cancer treated with multimodal treatment.
Lorenzo GervasoDavide CiardielloGiuliana GregatoLorenzo GuidiCarmine ValenzaLiliana AscioneLaura BoldriniSamuele FrassoniChiara Alessandra CellaFrancesca SpadaLuigi FunicelliGiuseppe De RobertoWanda PetzSimona BorinMarianna Alessandra GerardiLuca BottiglieriDarina TamayoEmilio BertaniUberto Fumagalli RomarioVincenzo BagnardiGiuseppe CuriglianoFrancesco BertoliniNicola FazioMaria Giulia ZampinoPublished in: Therapeutic advances in medical oncology (2024)
Within the limitations of a reduced number of patients, patients with baseline negative ctDNA seem to show a higher probability of pN0 status and a trend toward improved EFS. Prospective translational studies are required to define the role of ctDNA analysis in the multimodal treatment of LARC.