Primary, secondary and compensated male biochemical hypogonadism in people living with HIV (PLWH): relevance of sex hormone-binding globulin (SHBG) measurement and comparison between liquid chromatography-tandem mass spectrometry (LC-MS/MS) and chemiluminescent immunoassay for sex steroids assay.
Sara De VincentisMaria Chiara DecaroliFlaminia FanelliChiara DiazziMarco MezzulloGiulia TartaroSimonetta TagliaviniMaria Cristina De SantisLaura RoliJovana MilicTommaso TrentiUberto PagottoGiovanni GuaraldiVincenzo RochiraPublished in: The aging male : the official journal of the International Society for the Study of the Aging Male (2022)
The prevalence of male hypogonadism results underestimated by CI compared to LC-MS/MS in PLWH, both for TT and cFT. SHBG and gonadotropins are essential for detecting T deficiency.