Convergent network effects along the axis of gene expression during prostate cancer progression.

Konstantina CharmpiTiannan GuoQing ZhongUlrich WagnerRui SunNora C ToussaintChristine E FritzChunhui YuanHao ChenNiels J RuppAilsa ChristiansenDorothea RutishauserJan H RüschoffChristian FankhauserKarim SabaCedric PoyetThomas HermannsKathrin OehlAriane L MooreChristian BeiselLaurence CalzoneLoredana MartignettiQiushi ZhangYi ZhuMaría Rodríguez MartínezMatteo ManicaMichael C HaffnerRuedi AebersoldPeter J WildAndreas Beyer

Published in: Genome biology (2020)

This study uncovers molecular networks with considerable convergent alterations across tumor sites and patients. It also exposes a diversity of network effects: we could not identify a single sub-network that is perturbed in all high-grade tumor regions.

Keyphrases

prostate cancer
gene expression
high grade
end stage renal disease
ejection fraction
chronic kidney disease
dna methylation
low grade
prognostic factors
peritoneal dialysis
single molecule