Biomarker Analyses of Response to Cyclin-Dependent Kinase 4/6 Inhibition and Endocrine Therapy in Women with Treatment-Naïve Metastatic Breast Cancer.

Richard S FinnYuan LiuZhou ZhuMiguel MartinHope S RugoVéronique DiérasSeock-Ah ImKaren A GelmonNadia HarbeckDongrui R LuEric GauthierCynthia Huang BartlettDennis J Slamon

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

These data underscore the importance of CDK4/6 signaling in HR+/HER2- breast cancer and suggest that the interplay between steroid hormone and peptide growth factor signaling could drive dependence on CDK4/6 signaling.See related commentary by Anurag et al., p. 3.

Keyphrases

growth factor
cell cycle
metastatic breast cancer
stem cells
cell proliferation
big data
tyrosine kinase
cell death
young adults
deep learning
cell therapy