1 H-NMR-based metabolomics reveals metabolic alterations in early development of a mouse model of Angelman syndrome.
Pooja Kri GuptaSharon BarakYonatan FeuermannGil GoobesHanoch KaphzanPublished in: Molecular autism (2024)
Ube3a loss of function alters bioenergy-related metabolism in the AS brain during embryonic development. Furthermore, these neurochemical changes could be linked to the mitochondrial reactive oxygen species and oxidative stress that occurs during the AS embryonic development.
Keyphrases
- oxidative stress
- reactive oxygen species
- mouse model
- magnetic resonance
- mass spectrometry
- high resolution
- dna damage
- resting state
- diabetic rats
- white matter
- ischemia reperfusion injury
- induced apoptosis
- case report
- solid state
- functional connectivity
- multiple sclerosis
- cerebral ischemia
- heat shock
- endoplasmic reticulum stress