Body composition as a determinant of the therapeutic index with androgen signaling inhibition.
Andrew W HahnRebecca S Slack TidwellPatrick G PilieYao YuJingjing LiuDevaki Shilpa SurasiMark TitusJianhua ZhangNeha VenkateshTheocharis PanaretakisJustin R GreggAmado J ZuritaBilal A SiddiquiPaul G CornSumit K SubudhiPavlos MsaouelEfstratios KoutroumpakisChad D HuffAna M AparicioJennifer L McQuadeDaniel E FrigoChristopher L LogothetisPublished in: Prostate cancer and prostatic diseases (2024)
Inherited polymorphisms in androgen synthesis correlated with differences in body composition after exposure to ADT and warrant further investigation as candidate markers for body composition toxicity. Elevated subcutaneous and visceral adiposity were associated with improved response to ASI.