Potential effects of curcumin in the treatment of COVID-19 infection.
Fatemeh ZahedipourSeyede Atefe HosseiniThozhukat SathyapalanMuhammed MajeedTannaz JamialahmadiKhalid Al-RasadiMaciej BanachAmir Hossein SahebkarPublished in: Phytotherapy research : PTR (2020)
Coronavirus disease 2019 (COVID-19) outbreak is an ongoing pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with considerable mortality worldwide. The main clinical manifestation of COVID-19 is the presence of respiratory symptoms, but some patients develop severe cardiovascular and renal complications. There is an urgency to understand the mechanism by which this virus causes complications so as to develop treatment options. Curcumin, a natural polyphenolic compound, could be a potential treatment option for patients with coronavirus disease. In this study, we review some of the potential effects of curcumin such as inhibiting the entry of virus to the cell, inhibiting encapsulation of the virus and viral protease, as well as modulating various cellular signaling pathways. This review provides a basis for further research and development of clinical applications of curcumin for the treatment of newly emerged SARS-CoV-2.
Keyphrases
- sars cov
- coronavirus disease
- respiratory syndrome coronavirus
- signaling pathway
- end stage renal disease
- risk factors
- chronic kidney disease
- stem cells
- newly diagnosed
- type diabetes
- bone marrow
- depressive symptoms
- cell therapy
- cell proliferation
- oxidative stress
- patient reported outcomes
- prognostic factors
- pi k akt
- drug induced
- respiratory tract