Behavioral and Neuropathological Phenotyping of the Tau58/2 and Tau58/4 Transgenic Mouse Models for FTDP-17.
Debby Van DamFemke ValkenburgKristof Van KolenIsabel PintelonJean-Pierre TimmermansPeter Paul de DeynPublished in: Life (Basel, Switzerland) (2023)
Our findings indicate the face and construct validity of both Tau58 models, which may provide new, valuable insights into the pathologic effects of tau species in vivo and may consequently facilitate the development of new therapeutic targets to delay or halt neurodegenerative processes occurring in tauopathies.