Models for calcific aortic valve disease in vivo and in vitro.
Zijin ZhuZhirong LiuDonghui ZhangLi LiJianqiu PeiLin CaiPublished in: Cell regeneration (London, England) (2024)
Calcific Aortic Valve Disease (CAVD) is prevalent among the elderly as the most common valvular heart disease. Currently, no pharmaceutical interventions can effectively reverse or prevent CAVD, making valve replacement the primary therapeutic recourse. Extensive research spanning decades has contributed to the establishment of animal and in vitro cell models, which facilitates a deeper understanding of the pathophysiological progression and underlying mechanisms of CAVD. In this review, we provide a comprehensive summary and analysis of the strengths and limitations associated with commonly employed models for the study of valve calcification. We specifically emphasize the advancements in three-dimensional culture technologies, which replicate the structural complexity of the valve. Furthermore, we delve into prospective recommendations for advancing in vivo and in vitro model studies of CAVD.
Keyphrases
- aortic valve
- transcatheter aortic valve replacement
- aortic stenosis
- aortic valve replacement
- transcatheter aortic valve implantation
- single cell
- physical activity
- chronic kidney disease
- stem cells
- middle aged
- heart failure
- cell therapy
- pulmonary hypertension
- left ventricular
- atrial fibrillation
- community dwelling
- mesenchymal stem cells