Associations of FGF23 with 10-year change in eGFR and UACR with incident CKD in the CARDIA cohort.

Among middle-aged adults in the CARDIA cohort, median eGFR and UACR changes were modest and cFGF23 and iFGF23 were not consistently associated with 10-year change in eGFR or UACR. A non-linear relationship was observed between cFGF23 and incident CKD, with individuals with highest cFGF23 levels being at risk for developing CKD.