Clinical Applications of Adipose-Derived Stem Cell (ADSC) Exosomes in Tissue Regeneration.
Konstantinos S PapadopoulosChristina PiperiPenelope A KorkolopoulouPublished in: International journal of molecular sciences (2024)
Adipose-derived stem cells (ADSCs) are mesenchymal stem cells with a great potential for self-renewal and differentiation. Exosomes derived from ADSCs (ADSC-exos) can imitate their functions, carrying cargoes of bioactive molecules that may affect specific cellular targets and signaling processes. Recent evidence has shown that ADSC-exos can mediate tissue regeneration through the regulation of the inflammatory response, enhancement of cell proliferation, and induction of angiogenesis. At the same time, they may promote wound healing as well as the remodeling of the extracellular matrix. In combination with scaffolds, they present the future of cell-free therapies and promising adjuncts to reconstructive surgery with diverse tissue-specific functions and minimal adverse effects. In this review, we address the main characteristics and functional properties of ADSC-exos in tissue regeneration and explore their most recent clinical application in wound healing, musculoskeletal regeneration, dermatology, and plastic surgery as well as in tissue engineering.
Keyphrases
- wound healing
- stem cells
- tissue engineering
- mesenchymal stem cells
- extracellular matrix
- cell free
- inflammatory response
- cell proliferation
- umbilical cord
- minimally invasive
- cell therapy
- bone marrow
- lipopolysaccharide induced
- coronary artery bypass
- lps induced
- toll like receptor
- current status
- signaling pathway
- immune response
- atrial fibrillation
- vascular endothelial growth factor