ETAA1 ensures proper chromosome segregation: A matter of S phase or mitosis?

Marina Alejandra González BesteiroVanesa Gottifredi

Published in: The Journal of cell biology (2019)

ETAA1 activates the master checkpoint kinase ATR. Bass and Cortez (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201810058) recently reported an intra-mitotic function of ETAA1 that safeguards chromosome stability. In this issue, Achuthankutty et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201905064) describe a mechanism controlling the ATR-activating potential of ETAA1 in S phase to preserve chromosome stability.

Keyphrases

single cell
copy number
cell therapy
cell cycle
dna damage
signaling pathway
stem cells
gene expression
mesenchymal stem cells
dna methylation
risk assessment
tyrosine kinase