Novel Mutations in Obesity-related Genes in Turkish Children with Non-syndromic Early Onset Severe Obesity: A Multicentre Study

Ayşehan Akıncı Doga Turkkahraman İbrahim Tekedereli Leyla Özer Bahri Evren Ibrahim Sahin Tarkan Kalkan Yusuf Çürek Emine Çamtosun Esra Döğer Aysun Bideci Ayla Güven Erdal Eren Özlem Sangün Atilla Çayır Pelin Bilir Ayça Törel Ergür Oya Ercan

Published in: Journal of clinical research in pediatric endocrinology (2019)

We identified six novel and four previously described variants in six obesity-related genes in 11 out of 105 childrens with early onset severe obesity. The prevalence of monogenic obesity was 10.4% in our cohort.

Keyphrases

early onset
insulin resistance
metabolic syndrome
weight loss
late onset
high fat diet induced
type diabetes
weight gain
young adults
body mass index
gene expression
risk factors
dna methylation
autism spectrum disorder