Levels of angiopoietin-2 are predictive for mortality in yellow fever virus infected patients.
Cornelia A M van de WegMateus Vailant ThomazellaMariana P MarmoratoCarolina A CorreiaJuliana Z C DiasAlvino MaestriLuiz G F A B E ZanellaNatalia B CerqueiraAlvina C FélixCarlos H V MoreiraRenata BuccheriPriscilla R CostaEsper G KallásPublished in: The Journal of infectious diseases (2023)
In 2018 there was a large yellow fever outbreak in São Paulo, Brazil, with a high fatality rate. Yellow fever virus can cause, among other symptoms, haemorrhage and disseminated intravascular coagulation, indicating a role for endothelial cells in the disease pathogenesis. Here, we conducted a case-control study and measured markers related to endothelial damage in plasma and its association with mortality. We found that angiopoietin-2 is strongly associated with a fatal outcome and could serve as a predictive marker for mortality. This could be used to monitor severe patients and provide care to improve disease outcome.
Keyphrases
- endothelial cells
- cardiovascular events
- end stage renal disease
- healthcare
- ejection fraction
- chronic kidney disease
- risk factors
- newly diagnosed
- peritoneal dialysis
- palliative care
- cardiovascular disease
- early onset
- type diabetes
- coronary artery disease
- quality improvement
- patient reported outcomes
- depressive symptoms
- chronic pain
- drug induced