Leveraging metabolic modeling to identify functional metabolic alterations associated with COVID-19 disease severity.
Lillian R DillardN WaseG RamakrishnanJ J ParkN E ShermanR CarpenterM YoungA N DonlanW PetriJ A PapinPublished in: Metabolomics : Official journal of the Metabolomic Society (2022)
Our findings highlight the metabolic transition from an innate immune response coupled with inflammatory pathway inhibition in non-acute infection to rampant inflammation and associated metabolic systemic dysfunction in severe COVID-19.