Hypoalbuminaemia segregates different prognostic subgroups within the refined standard risk acute graft-versus-host disease score.
Mohamed A Kharfan-DabajaKyle SheetsAmbuj KumarHemant S MurthyTaiga NishihoriAthanasios TsalatsanisAlain MinaJohn MathewsErnesto AyalaJulio ChavezLia E PerezBrian C BettsClaudio AnasettiJoseph PidalaPublished in: British journal of haematology (2018)
Hypoalbuminaemia has been previously described to predict worse non-relapse mortality (NRM) and inferior overall survival (OS) in allogeneic haematopoietic cell transplant (allo-HCT) recipients. Here, we evaluate the role of hypoalbuminaemia (<35 g/l) at time of onset of acute graft-versus-host disease (aGVHD) when incorporated into the refined aGVHD score. The study population consisted of 522 patients, median age 53 (18-75) years, who underwent an allo-HCT mostly for haematological malignancies. Standard risk (SR) aGVHD comprised 467 patients (89%) and the number of high risk (HR) cases was 55 (11%). Median follow-up for all surviving patients was 26 (3-55) months. Two-year OS was significantly better in patients with SR aGVHD with a serum albumin ≥35 g/l compared to SR with albumin <35 g/l [70% (95% CI = 64-76%) vs. 49% (95% CI = 42-56%), P < 0·0001]. Also, patients with SR aGVHD and a serum albumin level of ≥35 g/l had a significantly lower NRM at 1-year post-transplantation [6% (95% CI = 3-10%) vs. 25% (95% CI = 20-32%), P < 0·0001]. After our findings are validated in a large cohort of patients, we propose that hypoalbuminaemia should be incorporated into the refined aGVHD risk score to further its ability to predict outcomes within this group.
Keyphrases
- end stage renal disease
- newly diagnosed
- ejection fraction
- prognostic factors
- stem cells
- bone marrow
- low dose
- liver failure
- single cell
- patient reported outcomes
- metabolic syndrome
- risk factors
- coronary artery disease
- extracorporeal membrane oxygenation
- cell death
- acute respiratory distress syndrome
- aortic dissection
- kidney transplantation