Splenic CD169 + Tim4 + Marginal Metallophilic Macrophages Are Essential for Wound Healing After Myocardial Infarction.

Mohamed Ameen IsmahilGuihua ZhouMin GaoShyam S BansalBindiya PatelNita LimdiMin Xie Sergey AntipenkoGregg RokoshTariq HamidSumanth D Prabhu

Published in: medRxiv : the preprint server for health sciences (2024)

This study highlights the importance of the cardiosplenic axis in acute MI, and the splenic marginal zone, in determining the course and outcome of post-MI LV remodeling.Pharmacological expansion of splenic marginal zone macrophages alleviated post-MI adverse LV remodeling and inflammation, suggesting that splenic modulation is a potential translational therapeutic approach for limiting post-MI inflammation and improving heart repair.

Keyphrases

oxidative stress
wound healing
liver failure
heart failure
emergency department
atrial fibrillation
intensive care unit
risk assessment
drug induced
hepatitis b virus
aortic dissection
mechanical ventilation