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Spontaneous DNA-RNA hybrids: differential impacts throughout the cell cycle.

Belén Gómez-GonzálezSonia I BarrosoEmilia Herrera-MoyanoAndrés Aguilera
Published in: Cell cycle (Georgetown, Tex.) (2020)
A large body of research supports that transcription plays a major role among the many sources of replicative stress contributing to genome instability. It is therefore not surprising that the DNA damage response has a role in the prevention of transcription-induced threatening events such as the formation of DNA-RNA hybrids, as we have recently found through an siRNA screening. Three major DDR pathways were defined to participate in the protection against DNA-RNA hybrids: ATM/CHK2, ATR/CHK1 and Postreplication Repair (PRR). Based on these observations, we envision different scenarios of DNA-RNA hybridization and their consequent DNA damage.
Keyphrases
  • dna damage response
  • nucleic acid
  • circulating tumor
  • cell cycle
  • dna damage
  • single molecule
  • dna repair
  • cell free
  • cell proliferation
  • oxidative stress
  • climate change
  • circulating tumor cells