Network exploration of gene signatures underlying low birth weight induced metabolic alterations.

Fei ZhouTiantian ChengYuling XingHui-Juan MaLinlin Yang

Published in: Medicine (2022)

A total of 326 DEGs and 10 hub genes were identified as candidates for metabolic disorders in LBW individuals. Our results indicated PI3K/AKT signaling pathway as an intrauterine adaptive mechanism for LBW individuals. We observed activated PI3K/AKT pathway in LBW individuals, which would promote growth and development at the early stage of life, but adversely introduce extra metabolic stress and thereby potentially induce metabolic disorders in adulthood.

Keyphrases

pi k akt
signaling pathway
low birth weight
early stage
genome wide
preterm infants
cell proliferation
cell cycle arrest
preterm birth
squamous cell carcinoma
oxidative stress
high glucose
copy number
genome wide analysis
sentinel lymph node