Enhanced Ca2+-Driven Arrhythmias in Female Patients with Atrial Fibrillation: Insights from Computational Modeling.

Xianwei ZhangYixuan WuCharlotte SmithWilliam E LouchStefano MorottiDobromir DobrevEleonora GrandiHaibo Ni

Published in: bioRxiv : the preprint server for biology (2024)

Our sex-specific computational models of human atrial cardiomyocytes uncover increased propensity to Ca2+-driven arrhythmogenic events in female compared to male atrial cardiomyocytes in AF, and point to combined Ca2+-targeted interventions as promising approaches to treat AF in female patients. Our study establishes that AF treatment may benefit from sex-dependent strategies informed by sex-specific mechanisms.

Keyphrases

atrial fibrillation
end stage renal disease
left atrial
endothelial cells
ejection fraction
newly diagnosed
chronic kidney disease
physical activity
prognostic factors
peritoneal dialysis
high glucose
cancer therapy
drug delivery
patient reported outcomes
left ventricular
combination therapy