The role of FAS, FAS-L, BAX, and BCL-2 gene polymorphisms in determining susceptibility to unexplained recurrent pregnancy loss.
Rafael Tomoya MichitaFrancis Maria Báo ZambraLucas Rosa FragaMaria Teresa SanseverinoLavínia Schuler-FacciniJosé Artur Bogo ChiesPriscila ViannaPublished in: Journal of assisted reproduction and genetics (2019)
Our study is the first to evaluate the role of the main SNPs from both the extrinsic and intrinsic apoptosis pathways in RPL susceptibility. The association of BAX-248G/A with RPL susceptibility suggests that maternal predisposition for RPL has an essential contribution from genes involved in the delicate balance of endometrium cell turnover (cell death/proliferation). Therefore, apoptotic genes may represent promising targets for future studies on healthy pregnancies and the spectrum of pregnancy disorders.
Keyphrases
- cell death
- pregnancy outcomes
- preterm birth
- cell cycle arrest
- genome wide
- oxidative stress
- induced apoptosis
- pregnant women
- signaling pathway
- single cell
- endoplasmic reticulum stress
- cell therapy
- stem cells
- gene expression
- transcription factor
- body composition
- weight loss
- mesenchymal stem cells
- weight gain
- genome wide analysis