From a syncytium to mononucleate cells and back: Yki and JNK in symphony.

Dhananjay Chaturvedi Krishnaswamy VijayRaghavan

Published in: The Journal of cell biology (2019)

Alary muscle syncytia in Drosophila larvae undergo a remarkable process of dedifferentiation into single cells that then fuse to become ventral longitudinal muscle in the adult. In this issue, Schaub et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201905048) identify the Hippo and JNK signaling pathways as key regulators of this process of developmental remodeling of cell fate.

Keyphrases

induced apoptosis
signaling pathway
endoplasmic reticulum stress
cell cycle arrest
cell fate
cell death
oxidative stress
skeletal muscle
pi k akt
spinal cord
stem cells
epithelial mesenchymal transition
transcription factor
cell proliferation