Germline and somatic genetic alterations in two first-degree relatives with appendiceal low-grade mucinous carcinoma peritonei.

Mary Caitlin King Carlos A Munoz-ZuluagaPanayotis LedakisKimberley StudemanMichelle Sittig Vadim Gushchin Armando Sardi

Published in: Clinical case reports (2020)

Comparing genetic mutations of first-degree relatives with appendiceal pseudomyxoma peritonei may explain clinical outcomes and disease pathogenesis. Molecular profiling of mucinous tumors may identify improved treatments to traditional chemotherapy.

Keyphrases

low grade
high grade
copy number
genome wide
locally advanced
single cell
squamous cell carcinoma
radiation therapy
single molecule
oxidative stress
gene expression