The Association of uPA, uPAR, and suPAR System with Inflammation and Joint Damage in Rheumatoid Arthritis: suPAR as a Biomarker in the Light of a Personalized Medicine Perspective.
Maurizio BenucciArianna DamianiEdda RussoSerena GuiducciFrancesca Li GobbiPaola FusiValentina GrossiAmedeo AmedeiMariangela ManfrediMaria InfantinoPublished in: Journal of personalized medicine (2022)
Available evidence about suPAR utility in the RA field is promising, and future research should further investigate its use in clinical practice, resulting in a big step forward for precision medicine. As it is elevated in different types of inflammation, suPAR could potentially work as an adjunctive tool for the screening of RA patients. In addition, a suPAR system has been shown to be involved in RA pathogenesis, so new data about the therapeutic response to Jak inhibitors can represent a possible way to develop further studies.
Keyphrases
- rheumatoid arthritis
- disease activity
- oxidative stress
- end stage renal disease
- clinical practice
- ankylosing spondylitis
- ejection fraction
- big data
- newly diagnosed
- chronic kidney disease
- interstitial lung disease
- peritoneal dialysis
- prognostic factors
- patient reported outcomes
- electronic health record
- machine learning
- current status
- artificial intelligence
- deep learning