Circulating Tumor DNA Assay Detects Merkel Cell Carcinoma Recurrence, Disease Progression, and Minimal Residual Disease: Surveillance and Prognostic Implications.
Tomoko AkaikeManisha ThakuriaAnn W SilkDaniel S HippeSong Youn ParkNaomi A SoNolan J MaloneyLindsay GunnellAlec EschholzEmily Y KimSumi SinhaEvan Thomas HallShailender BhatiaSunil ReddyAngel Augusto RodriguezAlexey AleshinJacob S ChoiKenneth Y TsaiSue S YomSiegrid S YuJaehyuk ChoiSunandana ChandraPaul T NghiemLisa C ZabaPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2024)
ctDNA testing exhibited high prognostic accuracy in detecting MCC recurrence, suggesting its potential to reduce frequent surveillance imaging. ctDNA also identifies high-risk patients who need more frequent imaging and may be best suited for adjuvant therapy trials.