Phagocytosis of Glioma Cells Enhances the Immunosuppressive Phenotype of Bone Marrow-Derived Macrophages.
Min WuLingxiang WuWei WuMengyan ZhuJianyu LiZiyu WangJie LiRong DingYuan LiangLiangyu LiTingting ZhangBin HuangYun CaiKening LiLu LiRui ZhangBaoli HuFan LinXiuxing WangSiyuan ZhengJian ChenYongping YouTao JiangJunxia ZhangHongshan ChenQiang-Hu WangPublished in: Cancer research (2023)
Bone marrow-derived macrophages phagocytose glioblastoma cells to form double-positive cells, dually expressing macrophage and tumor signatures that are transformed into M2-like macrophages and drive immunosuppression.