Orlistat and metformin combination ameliorates obesity-induced renal injury via suppressing renal oxidative stress in male rats.
Khadeejah AlsolamiReham Z HamzaPublished in: Toxicology research (2024)
The data displayed that the combination of both ORS and MEF declined the obesity effects significantly by reducing the level of peroxidation (MDA), and enhancement intracellular antioxidant enzymes. These biochemical findings were supported by histopathology, immunohistochemistry, and Masson-Trichrome evaluation, which showed minor morphological changes in the kidneys of rats.
Keyphrases
- oxidative stress
- insulin resistance
- diabetic rats
- metabolic syndrome
- weight loss
- type diabetes
- high fat diet induced
- weight gain
- high glucose
- dna damage
- signaling pathway
- electronic health record
- breast cancer cells
- big data
- ischemia reperfusion injury
- induced apoptosis
- anti inflammatory
- mouse model
- adipose tissue
- machine learning
- reactive oxygen species
- physical activity
- artificial intelligence
- body mass index
- cell death
- heat shock protein