Association of SCN1A, SCN2A, and UGT2B7 Polymorphisms with Responsiveness to Valproic Acid in the Treatment of Epilepsy.

Yuan Lu Quanping SuMing LiAlimu DayimuXiaoyu Dai Zhiheng Wang Fengyuan Che Xiaokang Ji

Published in: BioMed research international (2020)

The study indicated that eight SNPs and SNP-SNP interaction may be associated with VPA responses in Chinese Han epileptic patients. The SNPs were rs1381105 (SCN1A), rs2162600 (SCN1A), rs10197716 (SCN2A), rs2119068 (SCN2A), rs2119067 (SCN2A), rs353116 (SCN2A), rs353112 (SCN2A) and rs6740895 (SCN2A), respectively. The interaction between the three pairs of rs10197716-rs2119068, rs10197716-rs11889342 and rs7598931-rs12233719 was the most significant for VPA. This implied that these SNPs may play an important role in the pharmacogenomics mechanism of valproic acid.

Keyphrases

genome wide
emergency department
end stage renal disease
gene expression
chronic kidney disease
newly diagnosed
dna methylation
peritoneal dialysis
patient reported outcomes
smoking cessation
clinical decision support