Gancao Nourishing-Yin decoction combined with methotrexate in treatment of aging CIA mice: a study based on DIA proteomic analysis.

Yong ChenXing-Wang ZhuWing-Fu LaiYong-Pu LiuXuan-Feng XuLi-Ming LiuYan-Juan ChenChuan-Fu ZhangGuang-Yi WangZhi-Qiang ChengDong-Zhou Liu

Published in: Chinese medicine (2023)

Aging aggravated joints damage in CIA, which probably due to metabolic changes rather than more severe inflammation. GCNY showed significant effects in the ERA mice model especially when integrated with MTX to obtain a synergic action.

Keyphrases

oxidative stress
high fat diet induced
high dose
early onset
type diabetes
low dose
drug induced
replacement therapy