Cognitive and functional performance and plasma biomarkers of early Alzheimer's disease in Down syndrome.
Emily K SchworerBenjamin L HandenMelissa PetersenSid O'BryantJamie C PevenDana L TudorascuLaisze LeeSharon J Krinsky-McHaleChristy L HomIsabel C H ClareBradley T ChristianNicole SchupfJoseph H LeeElizabeth HeadMark MapstoneIra LottBeau M AncesShahid ZamanAdam M BrickmanFlorence LaiH Diana RosasSigan L Hartleynull nullPublished in: Alzheimer's & dementia (Amsterdam, Netherlands) (2024)
Plasma Alzheimer's disease (AD) biomarkers correlate with cognition prior to dementia in Down syndrome.Lower plasma amyloid beta 42/40 was related to lower visuospatial abilities.Higher plasma total tau and neurofilament light chain were associated with lower cognitive performance.Plasma biomarkers show potential for tracking early stages of AD symptomology.